Dr. Neuenschwander received his BS degree in Chemistry from the Rochester Institute
of Technology, NY in 1985, and his doctorate in Biochemistry & Molecular Biology from
Stony Brook University, NY in 1990. He then joined the Cardiovascular Biology research
group at the Oklahoma Medical Research Foundation as a postdoctoral fellow doing basic
biomedical research in the area of thrombosis and hemostasis with a focus on enzymology
and protein structure/function studies, becoming an Assistant Member in 1995.
In 2001, Dr. Neuenschwander accepted a position here at The University of Texas Health
Science Center at Tyler as an Associate Professor of Biochemistry to continue his
work. Although his historical focus has been on research, he has maintained a keen
interest in instruction and has been involved in educational activities here at the
University since his arrival. He was appointed as the Director of the Master of Science
in Biotechnology degree program in 2010, and was intimately involved in setting up
this inaugural degree program and sheparding the institution through the initial SACSCOC
accreditation process from 2012-2015. He currently serves the University as Senior
Associate Provost and holds the faculty rank of Professor of Cellular & Molecular
Biology. In additional to his administrative responsibilities, Dr. Neuenschwander
maintains his involvement in research and teaching and was awarded the Regent’s Outstanding
Teaching Award in 2014. His research has been funded by the NIH/NHLBI as well as the
AHA and he is currently involved in AHA-funded research related to the development
of hemocompatible surfaces. His other research interests involve studies of the role
of coagulation in the pathogenesis and propagation of pulmonary distress in influenza,
as well as Molecular Dynamics simulations of various coagulation complexes using the
Stampede2 supercomputer at the Texas Advanced Computing Center in Austin.
Education & Training
Oklahoma Medical Research Foundation
Postdoctoral Fellowship, Cardiovascular Biology, 1995
Stony Brook University
PhD, Biochemistry & Molecular Biology, 1990
Rochester Institute of Technology (RIT)
B.S., Chemistry, 1985
Courses Taught
BIOT 5131 Critical Reading I
BIOT 5221L Proteins & Nucleic Acids Lab
BIOT 5312 Molecular Biochemistry
BIOT 5132 Critical Reading II (Team Lecturer, 1 Module)
BIOT 6311 Biotechnology I (Team Lecturer, 1 Module: “DNA Strategies for Protein Expression”)
BIOT 6312 Biotechnology II (Team Lecturer, 2 Modules: “Protein-Protein Interactions-Biacore”;
“Microarrays”)
BIOT 6336 Biophysical Chemistry (Team Lecturer, 5 Modules: “UV/vis Spectroscopy”;
“3D Protein Structure Determination-Xray Crystallography and NMR”; “Mass Spectrometry”;
“Surface Plasmon Resonance”)
Research Interest
Enzymology and protein structure/function studies of the coagulation system.
Generation and characterization of hemocompatible/thromboresistant biomembrane-mimetic
coatings for artificial surfaces.
The role of coagulation in the pathogenesis and propagation of pulmonary distress
in influenza.
Molecular Dynamics simulation studies and molecular modeling of coagulation complexes.
Publication Highlights
Neuenschwander, P. F. (2004). Exosite occupation by heparin enhances the reactivity
of blood coagulation factor IXa. Biochemistry, 43(10), 2978–2986. https://doi.org/10.1021/bi035452d
Neuenschwander, P. F., Williamson, S. R., Nalian, A., & Baker-Deadmond, K. J. (2006).
Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type
inhibitor domains. The Journal of Biological Chemistry, 281(32), 23066–74. https://doi.org/10.1074/jbc.M603743200
Neuenschwander, P. F., Deadmond, K. J., Zepeda, K., & Rutland, J. (2012). Correlation
of factor IXa subsite modulations with effects on substrate discrimination. Journal
of Thrombosis and Haemostasis, 10(3), 382–389. https://doi.org/10.1111/j.1538-7836.2011.04605.x
Subramaniam, R., Barnes, P. F., Fletcher, K., Boggaram, V., Hillberry, Z., Neuenschwander,
P., & Shams, H. (2014). Protecting against post-influenza bacterial pneumonia by increasing
phagocyte recruitment and ROS production. Journal of Infectious Diseases, 209(11),
1827-1836. https://doi.org/10.1093/infdis/jit830
Subramaniam, R., Hillberry, Z., Chen, H., Feng, Y., Fletcher, K., Neuenschwander,
P., & Shams, H. (2015). Delivery of GM-CSF to protect against influenza pneumonia.
PLoS ONE, 10(4): e0124593. https://doi.org/10.1371/journal.pone.0124593
Gizaw, M., Thompson, J., Faglie, A., Lee, S.-Y., Neuenschwander, P., & Chou, S.-F.
(2018). Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery
in Wound Healing Applications. Bioengineering, 5: 9. https://doi.org/10.3390/bioengineering5010009
Small, M., Faglie, A., Craig, A. J., Pieper, M., Narcisse, V. E. F., Neuenschwander,
P. F., & Chou, S. F. (2018). Nanostructure-enabled and macromolecule-grafted surfaces
for biomedical applications. Micromachines, 9: 243. https://doi.org/10.3390/mi9050243
