Pierre Neuenschwander

Sr Associate Provost

Phone: 903.877.7678
Email: pierre.neuenschwander@uthct.edu
Department: Center For Biomedical Research

Dr. Neuenschwander received his BS degree in Chemistry from the Rochester Institute of Technology, NY in 1985, and his doctorate in Biochemistry & Molecular Biology from Stony Brook University, NY in 1990. He then joined the Cardiovascular Biology research group at the Oklahoma Medical Research Foundation as a postdoctoral fellow doing basic biomedical research in the area of thrombosis and hemostasis with a focus on enzymology and protein structure/function studies, becoming an Assistant Member in 1995. In 2001, Dr. Neuenschwander accepted a position here at The University of Texas Health Science Center at Tyler as an Associate Professor of Biochemistry to continue his work. Although his historical focus has been on research, he has maintained a keen interest in instruction and has been involved in educational activities here at the University since his arrival. He was appointed as the Director of the Master of Science in Biotechnology degree program in 2010, and was intimately involved in setting up this inaugural degree program and sheparding the institution through the initial SACSCOC accreditation process from 2012-2015. He currently serves the University as Senior Associate Provost and holds the faculty rank of Professor of Cellular & Molecular Biology. In additional to his administrative responsibilities, Dr. Neuenschwander maintains his involvement in research and teaching and was awarded the Regent’s Outstanding Teaching Award in 2014. His research has been funded by the NIH/NHLBI as well as the AHA and he is currently involved in AHA-funded research related to the development of hemocompatible surfaces. His other research interests involve studies of the role of coagulation in the pathogenesis and propagation of pulmonary distress in influenza, as well as Molecular Dynamics simulations of various coagulation complexes using the Stampede2 supercomputer at the Texas Advanced Computing Center in Austin. Education & Training Oklahoma Medical Research Foundation Postdoctoral Fellowship, Cardiovascular Biology, 1995 Stony Brook University PhD, Biochemistry & Molecular Biology, 1990 Rochester Institute of Technology (RIT) B.S., Chemistry, 1985 Courses Taught BIOT 5131 Critical Reading I BIOT 5221L Proteins & Nucleic Acids Lab BIOT 5312 Molecular Biochemistry BIOT 5132 Critical Reading II (Team Lecturer, 1 Module) BIOT 6311 Biotechnology I (Team Lecturer, 1 Module: “DNA Strategies for Protein Expression”) BIOT 6312 Biotechnology II (Team Lecturer, 2 Modules: “Protein-Protein Interactions-Biacore”; “Microarrays”) BIOT 6336 Biophysical Chemistry (Team Lecturer, 5 Modules: “UV/vis Spectroscopy”; “3D Protein Structure Determination-Xray Crystallography and NMR”; “Mass Spectrometry”; “Surface Plasmon Resonance”) Research Interest Enzymology and protein structure/function studies of the coagulation system. Generation and characterization of hemocompatible/thromboresistant biomembrane-mimetic coatings for artificial surfaces. The role of coagulation in the pathogenesis and propagation of pulmonary distress in influenza. Molecular Dynamics simulation studies and molecular modeling of coagulation complexes. Publication Highlights Neuenschwander, P. F. (2004). Exosite occupation by heparin enhances the reactivity of blood coagulation factor IXa. Biochemistry, 43(10), 2978–2986. https://doi.org/10.1021/bi035452d Neuenschwander, P. F., Williamson, S. R., Nalian, A., & Baker-Deadmond, K. J. (2006). Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains. The Journal of Biological Chemistry, 281(32), 23066–74. https://doi.org/10.1074/jbc.M603743200 Neuenschwander, P. F., Deadmond, K. J., Zepeda, K., & Rutland, J. (2012). Correlation of factor IXa subsite modulations with effects on substrate discrimination. Journal of Thrombosis and Haemostasis, 10(3), 382–389. https://doi.org/10.1111/j.1538-7836.2011.04605.x Subramaniam, R., Barnes, P. F., Fletcher, K., Boggaram, V., Hillberry, Z., Neuenschwander, P., & Shams, H. (2014). Protecting against post-influenza bacterial pneumonia by increasing phagocyte recruitment and ROS production. Journal of Infectious Diseases, 209(11), 1827-1836. https://doi.org/10.1093/infdis/jit830 Subramaniam, R., Hillberry, Z., Chen, H., Feng, Y., Fletcher, K., Neuenschwander, P., & Shams, H. (2015). Delivery of GM-CSF to protect against influenza pneumonia. PLoS ONE, 10(4): e0124593. https://doi.org/10.1371/journal.pone.0124593 Gizaw, M., Thompson, J., Faglie, A., Lee, S.-Y., Neuenschwander, P., & Chou, S.-F. (2018). Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications. Bioengineering, 5: 9. https://doi.org/10.3390/bioengineering5010009 Small, M., Faglie, A., Craig, A. J., Pieper, M., Narcisse, V. E. F., Neuenschwander, P. F., & Chou, S. F. (2018). Nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications. Micromachines, 9: 243. https://doi.org/10.3390/mi9050243