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Amy Tvinnereim

Amy Tvinnereim, PhD

Associate Professor, Director

Phone: 903.877.5189
Email: amy.tvinnereim@uttyler.edu
Department: Cellular and Molecular Biology

Dr. Tvinnereim is a Professor of Cellular and Molecular Biology and the Director of the Animal and Biosafety program.  She is an instructor in both the Biotechnology program and the School of Medicine.  Dr. Tvinnereim was trained as an Immunologist and Microbiologist at the Medical College of Wisconsin and earned her Ph.D. in 1998.  Dr. Tvinnereim came to the University of Texas Health Science Center at Tyler as a postdoctoral fellow in 2002 and joined the faculty in 2007.  Dr. Tvinnereim is an active instructor and teaching in the Master of Science in Biotechnology Program and the Medical School.  In addition, Dr. Tvinnereim helps organize the Summer Extern program and provides a hands-on lab experience in this program and in the Pre-Jamp Camp.  As Director of the Animal and Biosafety Program, Dr. Tvinnereim is responsible for overseeing the ethical and compliance use of animals in research and teaching, as well as the safe and compliant conduct of research involving biohazardous materials including recombinant DNA, infectious organisms, and other biological hazards within the university.  Dr. Tvinnereim works closely with researchers, veterinarians, biosafety officers, and regulatory agencies to maintain high standards of animal welfare, biosafety, and compliance.

 

Education and Training

  • Senior Postdoctoral Fellow, University of Texas Health Science Center at Tyler, 2002-2007
  • Postdoctoral Fellow, University of Iowa, 1998-2002
  • Ph.D., Medical College of Wisconsin, 1992-1998
  • B.S., Bradley University, 1989-1992
  • A.S., Rock Valley College, 1987-1989

 

Courses Taught

  • BIOT 6335, Tissue Culture
  • BIOT 6340, DNA Forensics
  • BIOT 6334, Advanced Immunology
  • BIOT 6336, Biophysical Chemistry
  • BIOT 5211, Advanced Biotechniques
  • BIOT 6325, Biotech Internship
  • MEDI 8105, Defense
  • MEDI 8106, Invaders

 

Selected Publications

  • Tripathi D., Cheekatla S.S., Paidipally P., Radhakrishnan R.K., Welch E., Thandi R.S., Tvinnereim A.R., Vankayalapati R.  c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice.  Sci Rep. 2018 Feb 19;8(1):3310

  • Paidipally P., Tripathi D., Van A., Radhakrishnan R.K., Dhiman R., Venkatasubramanian S., Devalraju K.P., Tvinnereim A.R., Valluri V.L., Vankayalapati R.  Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium tuberculosis Infection.  J Infect Dis. 2018 Mar 28;217(8):1323-1333

  • Cheekatla S.S., Tripathi D., Venkatasubramanian S., Paidipally P., Welch E., Tvinnereim A.R., Nurieva R., and Vankayalapati R.: IL-21 Receptor Signaling is Essential for Optimal CD4+ T Cell Function and Control of Mycobacterium tuberculosis Infection in Mice. J. Immunol. 199(8);2815-2822. 2017.

  • Cortes, C., Rzomp, K.A., Tvinnereim, A., Scidmore, M.A., and Wizel, B.: Chlamydia pneumoniae inclusion membrane protein Cpn0585 interacts with several Rab GTPases. Infect Immun. 75:5586-5597. 2007.

  • Tvinnereim, A., and Wizel B.: CD8+ T cell protective immunity against Chlamydia pneumoniae includes an H2-M3-restricted response that is CD4+ T cell-independent. J. Immunol. 179:3947-57. 2007.

  • Pinchuk, I., Starcher, B., Livingston, B., Tvinnereim, A., Wu, S., Appella, E., Sidney, J., Sette, A., and Wizel, B.: A CD8+ T cell heptaepitope minigene vaccine induces protective immunity against Chlamydia pneumoniae. J. Immunol. 174:5729-39. 2005.

  • Tvinnereim, A., Hamilton, S.E., and Harty, J.T.: Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens. J. Immunol. 173:1994-2002. 2004

  • Badovinac, V. P., Tvinnereim, A.R., and Harty, J.T.: Regulation of antigen-specific CD8+ T cell homeostasis by Perforin and IFN-g. Science. 290(5495) 1354-1358. 2000

  • Tvinnereim, A.R., and Harty, J.T.: CD8+ T cell priming against a non-secreted Listeria monocytogenes antigen is independent of the anti-microbial activities of IFN-g. Infect. Immun. 68(4) 2196-2204. 2000.

  • Harty, J.T., Tvinnereim, A.R., and White, D.W.:  CD8+ T cell effector mechanisms in resistance to infection. Ann. Rev. Immunol. 18:275-308. 2000.